• Liver sinusoidal endothelial cells contribute to the uptake and degradation of entero bacterial viruses 

      Øie, Cristina Ionica; Wolfson, Deanna; Yasunori, Tanji; Dumitriu, Gianina; Sørensen, Karen Kristine; McCourt, Peter Anthony; Ahluwalia, Balpreet Singh; Smedsrød, Bård (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-21)
      The liver is constantly exposed to dietary antigens, viruses, and bacterial products with inflammatory potential. For decades cellular uptake of virus has been studied in connection with infection, while the few studies designed to look into clearance mechanisms focused mainly on the role of macrophages. In recent years, attention has been directed towards the liver sinusoidal endothelial cells ...
    • Uptake and Degradation of Bacteriophages by Liver Sinusoidal Endothelial Cells 

      Wolfson, Deanna; Øie, Cristina Ionica; Yasunori, Tanji; Dumitriu, Gianina; McCourt, Peter Anthony; Sørensen, Karen Kristine; Smedsrød, Bård; Ahluwalia, Balpreet Singh (Conference object; Konferansebidrag, 2018)
      <p>Bacteriophages (briefly, “phages”) are viruses which target bacteria, and are non-infectious to eukaryotic cells. It is estimated that more than 30 billion phages cross into the human body from the gut each day1, and eventually need to be cleared from the blood circulation. The liver plays a central role in pathogen clearance, and liver sinusoidal endothelial cells (LSECs), which form the lining ...